Fig. 5.

Network topologies for Off–On-Off switch. A Heatmap for all three-node networks in F₁-F₂ fold space. The red dashed-lined box marks the functional circuits with F₁ and F₂ $\ge 4$. B Distribution of all functional networks in the Q-value and edge number spaces. Black dashed-line boxes mark the simplest networks, and grey-lined dashed boxes are for best networks with Q-values $\ge 4$. C The simplest functional networks as marked in (B). D The best functional topologies with Q-values $\ge 8$. E Hierarchical clustering analyses for 72 functional networks with Q-values $\ge 4$