Fig. 6.

Parameter preference in functional topologies. The histograms of free energy changes $\mathrm{\Delta }{G}_{\mathit{ij}}$ (defined in the text) for Off–On functional motifs M₁, M₂, and M₃ (A), On–Off functional motifs M₁, M₄, M₅ (B), a high Q-value complex topology with 6 links (C), and for Off–On-Off functional motif M₆ (D). The distributions were generated from functional parameters that are screened from 1,000,000 Latin hypercubic samplings in the parameter space for each topology