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. 2022 May 24;20:121. doi: 10.1186/s12915-022-01326-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Prediabetic sheep suffer gut microbiota dysbiosis. A PCoA plot of gut microbiota based on the operational taxonomic unit metrics of samples in the three groups. B Bacterial taxonomic profiling at the phylum level of intestinal bacteria from the three groups. C Heatmap of differential abundance from the prediabetes and rescue groups, compared with the control group. D The differential abundance of intestinal bacteria at the genus level of (a) Clostridium_sensu_stricto_13, (b) Olsenella, (c) Christensenellaseae_R-7_group, (d) Erysipelotrichaceae_UCG_008, (e) [Eubacterium]_nodatum_group, (f) Syntrophococcus, (g) [Ruminococcu]_gauvreauii_group, (h) Marvinbyrantia, (i) Lachnospiraceae_UCG_002, and (j) Ruminococcaceae_NK4A214_group from the prediabetes and rescue groups compared with the control group (n = 9)