FIGURE 6.

Therapeutic effect of the nucleolin‐aptamer–conjugated gemcitabine–loaded atelocollagen patch in pancreatic cancer patient–derived xenograft model. The size of the implanted pancreatic cancer was found to be increasing with different tumor growth rates according to individual groups. Among them, the patch I group (necleolin‐aptamer–conjugated gemcitabine–loaded atelocollagen patch) showed the most significant reduction of tumor growth rate compared with the no‐treatment group. *Mann‐Whitney U, p < 0.05