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. 2022 Mar 29;113(5):1652–1668. doi: 10.1111/cas.15337

FIGURE 8.

FIGURE 8

Inhibition of exosomal miR‐106a‐5p attenuated nasopharyngeal carcinoma (NPC) growth and metastasis through the FBXW7‐TRIM24‐SRGN axis in vivo. HONE1 or SUNE‐1 cells were transfected with NC mimics or miR‐106a‐5p mimics, or cancer‐associated fibroblasts (CAFs) were transfected with NC inhibitor or miR‐106a‐5p inhibitor or treated with GW4689 and subsequently mixed with HONE1 or SUNE‐1 cells. HONE1 or SUNE‐1 cells or the mixture of CAFs and HONE1 or SUNE‐1 cells were subcutaneously or intravenously inoculated into nude mice. A, Excised tumors were imaged, measured, and weighed (n = 4). B, Lungs were excised and imaged. Metastatic nodules were calculated, and H&E staining was performed for evaluating lung damage (magnification, 200×; scale bar, 50 µm; n = 4). C, Protein levels of FBXW7, TRIM24, and SRGN in tumor tissues. *p < 0.05, **p < 0.01, and ***p < 0.001.