FIGURE 1.

Ubiquitin‐specific peptidase 10 (USP10) is abundantly expressed in pancreatic adenocarcinoma (PAAD) tissues signaling pathway enriched on the positive side of the YAP1 according to Gene Set Enrichment Analysis (GSEA and cells and positively correlated with YAP1. (A) Hydrolysis‐related); (B) genes show high correlation with YAP1 analyzed using a correlation test (cor. Test); (C) USP10 expression in TCGA‐PAAD and GTEx databases; (D) association between USP10 level and the prognosis of patients analyzed in TCGA‐PAAD; (E) staining intensity of USP10 in the PAAD tissues and normal pancreatic tissues in the HPA system; (F and G) expression of Cyr61 (F) and CTGF (G) in TCGA‐PAAD; (H and I) positive correlations between CTGF (H) and Cyr61 (I), and USP10 examined by Spearman's rank correlation coefficient; (J) expression of USP10 in PAAD cell lines (Capan‐2, AsPC‐1, Panc‐1, and BxPC‐1), and in the normal HPDE6 cells determined by RT‐qPCR. Differences were analyzed by one‐way ANOVA (J), ***P < 0.001