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. 2022 Apr 5;113(5):1868–1879. doi: 10.1111/cas.15326

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© 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Ubiquitin‐specific peptidase 10 (USP10) knockdown suppresses growth and metastasis of pancreatic adenocarcinoma (PAAD) cells in vivo. (A) Growth rate of the xenograft tumors; (B) weight of the xenograft tumors on the 35th day; (C–G) staining intensity of KI67 (C), PCNA (D), YAP1 (E), Cyr61 (F), and CTGF (G) in the tissues of xenograft tumors detected by IHC staining; and (H and I) tumor metastasis in murine lung (H) and liver (I) tissues on the 45th day examined by HE staining. In each group, n = 6. Differences were analyzed by two‐way ANOVA (A–E), **P < 0.01; ***P < 0.001