FIGURE 4.

Dahuang Fuzi Baijiang decoction (DFB) reduces tumor interstitial and serum chemokine (C‐C motif) ligand 2 (CCL2) production. Contents of key adipokines in tumor interstitial fluid and serum. Transforming growth factor‐β1 (TGF‐β1) in tumor interstitial fluid (A) and serum (D). Interleukin‐6 (IL‐6) in tumor interstitial fluid (B) and serum (E). CCL2 in tumor interstitial fluid (C) and serum (F). *P < .05, **P < .01, ***P < .001, compared with ob/ob (PBS) group. ^# P < .05, ^## P < .01, ^### P < .001, compared with ob/ob (anti‐programmed cell death‐1 [αPD‐1] + DFB) group,. Data in this figure are depicted as mean ± SEM, with all individual points shown. Ordinary one‐way ANOVA P values are shown