FIGURE 4.

Epigenetic regulations of cancer‐prone metabolism as a central oncogenic phenotype. Oncogene signaling reprograms central carbon metabolism at the outset. The effect of carbon metabolism reprogramming is far reaching, and globally shifts the epigenome of cancer cells including histone modifications and DNA methylation. Genome‐wide epigenetic changes eventually govern each specific, effector metabolism for tumor cell survival through the induction of cancer cell stemness. Ac, acetyl‐group; ac, acetylation; K, lysine residues; Me, methyl‐group; met, methylation