Fig. 3.

Localization of asthma-associated amino acid variants. Ribbon-figure representations of the peptide-binding pocket are shown for each HLA protein, and the amino acid variant in focus is highlighted. A HLA-C p.11, shown in blue, is located within the peptide-binding pocket of the HLA-C molecule [33] (forest green). B HLA-DQB1 p.55, shown in magenta, lies in the region that may interact with the TCR on the HLA-DQB1 [34] protein (gray) in complex with HLA-DQA1 (blue). C HLA-DQA1 p.26, p.47, p.56, and p.76 (green) shown on the HLA-DQA1 protein [35] (blue). p.26 lies in the peptide-binding pocket, p.76 in the region that may interact with the TCR, and p.56 and p.47 in regions outside of the peptide-binding pocket