Table 2.
Results of replication meta-analysis
| Group | CS | Variant | Allele (non-risk/risk) | p-value | OR | 95% CI |
|---|---|---|---|---|---|---|
| COA | Class I CS1 | rs2428494 | T/A | 9.72 × 10−04 | 1.13 | 1.05–1.21 |
| Class I CS2 | HLA-C p.11 | Ser/Ala | 2.66 × 10−03 | 1.16 | 1.05–1.29 | |
| Class II CS1 | rs28407950 | T/C | 1.30 × 10−09 | 1.29 | 1.19–1.40 | |
| Class II CS2 | rs35571244 | T/C | 2.74 × 10−01 | 1.08 | 0.94–1.25 | |
| AOA | Class I CS1 | rs2428494 | T/A | 1.27 × 10−02 | 1.06 | 1.01–1.12 |
| Class II CS1 | rs9274660 | A/G | 6.10 × 10−08 | 1.14 | 1.09–1.20 | |
| rs3828789 | G/T | 4.59 × 10−08 | 1.15 | 1.09–1.20 | ||
| rs1063355 | T/G | 4.31 × 10−08 | 1.15 | 1.09–1.20 | ||
| rs9272346 | G/A | 7.52 × 10−08 | 1.14 | 1.09–1.20 | ||
| Class II CS2 | HLA-DQA1 | *03:01 | 1.27 × 10−04 | 1.13 | 1.06–1.21 |
P-values, odds ratios (ORs), and 95% confidence intervals (95% CI) in the replication cohorts are reported for each of the candidate variants from the discovery COA and AOA credible sets