Table 1.
Baseline patient characteristics in pre-matched groups.
| Variables | Total | 501Y.V2 | Standardized difference | |
|---|---|---|---|---|
| (n = 218) | No (n = 135) | Yes (n = 83) | ||
| Patients evacuated by air from Mayotte to Reunion Island | 50 (22.9) | 13 (9.6%) | 37 (44.6%) | 0.85 |
| Delay between hospital admission and onset of symptoms (days) | 5 [2.5–7] | 5 [2–80] | 5 [3–7] | 0.15 |
| Delay between in ICU admission and onset of symptoms (days) | 8 [5–11] | 8 [5–11] | 7 [5–11] | 0.08 |
| Comorbidities | ||||
| Age (years old) | 62 [53–73] | 67 [56–74] | 58 [51–68] | − 0.42 |
| Male sex | 139 (63.8) | 81 (60) | 58 (69.9) | 0.21 |
| Body mass index > 25 kg/m2 | 163 (74.8) | 102 (75.6) | 61 (73.5) | − 0.05 |
| Cancer (< 3 months) | 5 (2.3) | 4 (3) | 1 (1.2) | − 0.12 |
| History of congestive heart failure | 37 (17) | 26 (19.3) | 11 (11.3) | − 0.16 |
| Diabetes mellitus | 95 (43.6) | 62 (45.9) | 33 (39.8) | − 0.12 |
| Hypertension | 137 (62.8) | 92 (68.1) | 45 (54.2) | − 0.29 |
| Chronic kidney disease | 54 (24.8) | 43 (31.9) | 11 (13.3) | − 0.45 |
| Chronic obstructive pulmonary disease | 34 (15.6) | 24 (17.8) | 10 (12) | − 0.16 |
| Immunodepression | 19 (8.7) | 13 (9.6) | 6 (7.2) | − 0.09 |
| During the first 24 h in ICU | ||||
| Simplified Acute Physiology Score 2 | 32 [25–43] | 34 [26–45] | 31 [24–38] | − 0.23 |
| High− flow oxygen therapy | 194 (89) | 125 (92.6) | 69 (83.3) | − 0.29 |
| Extent of lesions on initial CT scan > 50% | 100 (45.9) | 59 (45) | 41 (49.4) | 0.03 |
| *Severe ARDS | 49 (22.5) | 27 (20) | 22 (26.5) | 0.20 |
| Glasgow coma scale score | 15 [15–15] | 15 [15–15] | 15 [15–15] | − 0.14 |
| Enhanced thromboprophylaxis | 215 (98.6) | 132 (97.8) | 83 (100) | 0.21 |
| Corticosteroids | 185 (95.4) | 116 (94.3) | 69 (97.2) | 0.14 |
| Deworming with ivermectine | 55 (27.9) | 28 (23.1) | 27 (35.5) | 0.27 |
| C− reactive protein (mg/L) | 109 [69–177] | 123 [73–187] | 90 [68–169] | − 0.08 |
| Creatinin (µmol/L) | 93 [66–160] | 95 [65–173] | 90 [66–126] | − 0.32 |
| D− dimer level (µg/mL) | 1085 [609–2210] | 1037 [602–1790] | 1153 [693–3409] | 0.15 |
| Total bilirubin level (mg/dL) | 12 [8–16] | 12 [8–16] | 14 [7–20] | − 0.10 |
| Lactate dehydrogenase (IU/L) | 470 [374–605] | 498 [386–607] | 444 [369–539] | − 0.28 |
| Lymphocytes count (G/L) | 0.8 [0.48–1.17] | 0.8 [0.5–1.18] | 0.78 [0.44–1.05] | − 0.14 |
| Polynuclear neutrophils (G/L) | 6.57 [4.33–9.76] | 6.47 [4.54–8.98] | 6.86 [4.13–10.59] | 0.14 |
| Fibrinogen (g/L) | 6.1 [5.1—7.1] | 6.1 [5.1–7.1] | 5.9 [5.1—7.2] | 0.35 |
Results are expressed as total numbers (percentages) for categorical variables and as medians [25th–75th percentiles] for continuous variables as appropriate.
ARDS acute respiratory distress syndrome, CT computed tomography, ICU intensive care unit.
*Defined as PaO2/FIO2 ratio ≤ 100 mmHg with PEEP ≥ 5 cm H2O.