Table 2.
Baseline patient characteristics in propensity-matched groups.
| Variables | Total | 501Y.V2 variant | Standardized difference | |
|---|---|---|---|---|
| (n = 124) | No (n = 62) | Yes (n = 62) | ||
| Patients evacuated by air from Mayotte to Reunion Island | 29 (23.4) | 13 (21.0) | 16 (25.8) | 0.11 |
| Delay between hospital admission and onset of symptoms (days) | 5.5 [3–8] | 6 [3–10] | 5 [3–7] | 0.01 |
| Delay between in ICU admission and onset of symptoms (days) | 8 [5–11] | 10 [5–12] | 7 [5–10] | − 0.26 |
| Comorbidities | ||||
| Age (years old) | 60 [53–70] | 61 [56–70] | 60 [53–71] | 0.01 |
| Male sex | 39 (31.5) | 19 (30.6) | 20 (32.3) | − 0.03 |
| Body mass index > 25 kg/m2 | 93 (75) | 48 (77.4) | 45 (72.6) | − 0.11 |
| Cancer (< 3 months) | 4 (3.2) | 3 (4.8) | 1 (1.6) | − 0.18 |
| History of congestive heart failure | 21 (16.9) | 11 (17.7) | 10 (16.1) | − 0.04 |
| Diabetes mellitus | 46 (37.1) | 24 (38.7) | 22 (35.5) | − 0.07 |
| Hypertension | 64 (51.6) | 32 (51.6) | 32 (51.6) | 0 |
| Chronic kidney disease | 21 (16.9) | 10 (16.1) | 11 (17.7) | 0.04 |
| Chronic obstructive pulmonary disease | 16 (12.9) | 10 (16.1) | 11 (17.7) | 0.04 |
| Immunodepression | 11 (8.9) | 6 (9.7) | 5 (8.1) | − 0.06 |
| During the first 24 h in ICU | ||||
| Simplified Acute Physiology Score 2 | 31 [24–42] | 34 [24–46] | 27 [24–37] | − 0.23 |
| High-fow oxygen therapy | 109 (87.9) | 56 (90.3) | 53 (85.5) | − 0.12 |
| Extent of lesions on initial CT scan > 50% | 63 56.8) | 33 (62.3) | 30 (51.7) | − 0.18 |
| *Severe ARDS | 32 (25.8) | 15 (24.2) | 17 (27.4) | 0.06 |
| Glasgow coma scale score | 15 [15–15] | 15 [15–15] | 15 [15–15] | − 0.16 |
| Enhanced thromboprophylaxis | 124 (100) | 62 (100) | 62 (100) | 0 |
| Corticosteroids | 106 (95.5) | 53 (94.6) | 53 (96.4) | 0.08 |
| Deworming with ivermectine | 36 (31.9) | 16 (29.6) | 20 (33.9) | 0.09 |
| C-reactive protein (mg/L) | 106 [69–171] | 117 [73–176] | 90 [69–168] | − 0.12 |
| Creatinin (µmol/L) | 82 [64–132] | 78 [62–124] | 87 [68–160] | − 0.12 |
| D-dimer level (µg/mL) | 969 [589–1915] | 1271 [568–2393] | 884 [589–1846] | 0.43 |
| Lactate dehydrogenase (IU/L) | 448 [395–625] | 512 [463–625] | 445 [374–541] | − 0.16 |
| Lymphocytes count (G/L) | 0.83 [0.51–1.21] | 0.8 [0.5–1.14] | 0.84 [0.54–1.25] | − 0.17 |
| Polynuclear neutrophils (G/L) | 6.22 [4.07–9.97] | 6.22 [4.3–10.6] | 6.32 [3.97–9.71] | 0.04 |
| Fibrinogen (g/L) | 6 [5.1–7.12] | 6 [5.21–7.08] | 6.5 [5.09–7.36] | 0.14 |
ARDS acute respiratory distress syndrome, CT computed tomography, ICU intensive care unit.
Results are expressed as total numbers (percentages) for categorical variables and as medians [25th–75th percentiles] for continuous variables as appropriate.
*Defned as PaO2/FIO2 ratio ≤ 100 mmHg with PEEP ≥ 5 cm H2O.