Figure 2.

Voxel-wise group differences in ¹¹C-PBR28 signal. (A) Maps displaying areas with significantly elevated ¹¹C-PBR28 SUVR in cLBP_RAD compared to cLBP_AX in a voxelwise analysis, adjusted for protocol and genotype. (B) Average ± SD SUVR extracted from several clusters identified as statistically significant in the voxelwise SUVR analysis from A (adjusted for scanner and genotype). The range of the y-axis is set depending on the distribution of individual data-points. (C) BOLD functional MRI localizing the somatotopic representation of S1 area for the Back+Leg and the overlap between Back+Leg e-stim and ¹¹C-PBR28 SUVR signal in cLBP_RAD > cLBP_AX. IPS = intraparietal sulcus; PCC = posterior cingulate cortex; WM = white matter. Triangle denotes data from Protocol 1, circle denotes data from Protocol 2.