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. 2022 Apr 12;4(2):fcac095. doi: 10.1093/braincomms/fcac095

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Network reconfiguration dynamics per group at baseline. Global flexibility (P = 0.001) was higher in CI patients compared with preserved (CP) patients, showing that brain regions switch more frequently between resting-state networks. Cohesion (P = 0.001) was particularly increased in CI patients compared with preserved patients and not disjointedness, indicating that the increased reconfigurations particularly occurred for pairs of brain regions (i.e. mutual switches). MCI patients showed intermediate dynamics. This effect does not seem to be specific to a network, but rather general across the whole brain. The coloured points indicate dynamics of each participant per network and the distribution over all networks is represented to the left of them, within that distribution the mean and confidence interval of global values are depicted. The horizontal dotted lines represent the confidence interval of global measures for CP patients, included for readability.