TABLE 1.

Experimental and literature-derived parameters for simulated model of nerve conduction

Parameter	Value	Units
Resting potentiala	−82	mV
Leakage potentiala	−83.38	mV
Na+ reversal potentiala	50	mV
K+ reversal potentiala	−84	mV
Node diameter	0.77	μm
Node lengthb	1.67	μm
Internode lengthc	138	μm
Axon membrane capacitance at node and internoded	0.9	μF/cm2
Myelin membrane capacitanced	0.9	μF/cm2
4-week optic nerve
Mean g-ratio	0.6342	N/A
g-Ratio variance	0.0118	N/A
Mean axon diameter	0.5770	μm
Axon diameter variance	0.0777	μm
Percentage of Fast Nav nodes	17.10	%
Mean myelin thickness (derived)	0.9254	μm
Myelin thickness variance	0.1678	μm
5-week optic nerve
Mean g-ratio	0.6212	N/A
g-Ratio variance	0.0193	N/A
Mean axon diameter	0.7754	μm
Axon diameter variance	0.1003	μm
Percentage of Fast Nav nodes	18.80	%
Mean myelin thickness (derived)	1.246	μm
Myelin thickness variance	0.1924	μm
6-week optic nerve
Mean g-ratio	0.6228	N/A
g-Ratio variance	0.0195	N/A
Mean axon diameter	0.7827	μm
Axon diameter variance	0.1100	μm
Percentage of Fast Nav nodes	26.90	%
Mean myelin thickness (derived)	1.251	μm
Myelin thickness variance	0.2038	μm
8-week optic nerve
Mean g-ratio	0.6044	N/A
g-Ratio variance	0.0145	N/A
Mean axon diameter	0.7904	μm
Axon diameter variance	0.0888	μm
Percentage of Fast Nav nodes	34.70	%
Mean myelin thickness (derived)	1.325	μm
Myelin thickness variance	0.1969	μm
12-week optic nerve
Mean g-ratio	0.6163	N/A
g-ratio variance	0.0185	N/A
Mean axon diameter	0.7981	μm
Axon diameter variance	0.1070	μm
Percentage of Fast Nav nodes	32.50	%
Mean myelin thickness (derived)	1.313	μm
Myelin thickness variance	0.2314	μm

^aValues are from Arancibia-Cárcamo et al. (2017).

^bValues are from Gentet et al. (2000).

^cValues are from Rios et al. (2003).

^dValues are from Butt et al. (1994).