TABLE 1.
Synergistic effect on PlnAs and erythromycin
| PlnA category | MIC (μg/mL) of: |
MHC (μg/mL)a | MHC/MIC | FICIb | ||
|---|---|---|---|---|---|---|
| PlnA | Ery | Ery + PlnA | ||||
| PlnA1 | 25 | 500 | 32/6.25 | 480 | 12.8 | 0.314 |
| PlnA2 | 25 | 500 | 64/6.25 | 480 | 12.8 | 0.378 |
| PlnA3 | 12.5 | 500 | 64/6.25 | 60 | 3.2 | 0.628 |
| PlnA4 | 50 | 500 | 64/25 | 60 | 1.2 | 0.628 |
a
We defined the MHC as the highest peptide concentration that caused no detectable release of hemoglobin.
b
A FICI value of ≤0.5 indicates a synergistic effect, a value of >0.5 and ≤1 indicates an additive effect, a value of >1 and <2 indicates an indifferent effect, and a value of ≥2 indicates an antagonistic effect.