Table 1.
Clinical characteristics of patients left for downstream analysis, classified as recurrent wheezing RSV (RW-RSV), asthma RSV (AS-RSV), and complete recovery RSV cases (CR-RSV).
| CR-RSV (n = 28) | RW/AS-RSV (n = 40) | P-value | |
|---|---|---|---|
| Demographic variables | |||
| Sex Male | 17 (60.07%) | 28 (70.0%) | 0.447 |
| Age in months (mean [SD])* | 7.14 [5.32] | 5.85[3.62] | <0.001 |
| Ethnicity | 0.184 | ||
| Western Europe | 24 (85.7%) | 36 (90.0%) | – |
| Southern Europe | 2 (7.1%) | 1 (2.5%) | – |
| Southern America | 1 (3.6%) | 0 | – |
| Roma | 0 | 3 (7.5%) | – |
| Other | 1 (3.6%) | 0 | – |
| RSV infection | 28 (100.0%) | 40 (100.0%) | 1.000 |
| Past medical history prior to RSV-A | |||
| Premature | 4 (14.3%) | 4 (10.0%) | 0.717 |
| Atopic Dermatitis* | 2 (7.1%) | 13 (32.5%) | 0.017 |
| Alimentary allergies | 1 (3.6%) | 5 (12.5%) | 0.399 |
| Stational allergies | 0 | 2 (5.0%) | 0.508 |
| Asthma | 0 | 0 | 1.000 |
| Admissions prior to RSV | 10 (35.7%) | 12 (27.0%) | 0.399 |
| Annual bronchitis prior the RSV-A* | 3 (10.7%) | 21 (52.5%) | 0.005 |
| Family history | |||
| Asthma | 4 (14.3%) | 14 (35.0%) | 0.052 |
| Respiratory problems | 5 (17.9%) | 15 (37.5%) | 0.053 |
| Clinical characteristics of the RSV-H | |||
| Respiratory distress | 0.147 | ||
| Mild | 8 (28.6%) | 4 (10.0%) | |
| Moderate | 16 (57.1%) | 29 (72.5%) | |
| Severe | 4 (14.3%) | 7 (17.5%) | |
| Oxygen requirement | 23 (82.1%) | 25 (62.5%) | 0.107 |
| Respiratory support | 0.128 | ||
| Non-invasive | 3 (10.7%) | 8 (20%) | |
| Mechanical | 2 (7.1%) | 0 | |
| Diagnosis | 0.093 | ||
| Bronchiolitis | 25 (89.3%) | 31 (77.5%) | |
| Bronchospasm | 0 | 1 (2.5%) | |
| Pneumonia | 2 (7.1%) | 2 (5.0%) | |
| Other | 1 (3.6) | 6 (15.0%) | |
| Bacterial superinfection suspected* | 20 (71.4%) | 12 (30.0%) | <0.001 |
| Follow-up 3 years | |||
| Hospital admission | 5 (17.9%) | 11 (27.5%) | 0.962 |
| Additional episodes of bronchiolitis* | 7 (25%) | 37 (92.5%) | <0.001 |
Fisher’s exact test is used to assess the association between the different variables. RSV-A, RSV admission; RSV-H, RSV hospitalization.
*Statistically significant variables.