Table 2.
The 28 most significant DMPs in the comparison RSV sequelae patients vs. CR-RSV cases (FDR P-value < 0.01, absolute average β-value > 0.10).
| CpG_ID | Chr | Position | Location | GN | GG | P-Value | Delta β |
|---|---|---|---|---|---|---|---|
| cg21226224 | 8 | 55370171 | IS | SOX17 | TSS1500 | 3.29×10-04 | – 0.144 |
| cg24509398 | 1 | 28416532 | SS | EYA3 | TSS1500 | 2.77×10-10 | –0.136 |
| cg11702503 | 19 | 6215254 | IS | MLLT1 | Body | 2.43×10-03 | – 0.118 |
| cg00044440 | 5 | 138671449 | OS | – | – | 6.77×10-06 | –0.118 |
| cg15619333 | 12 | 133759653 | SS | ZNF268 | 5’UTR; Body | 4.39×10-09 | –0.116 |
| cg05800416 | 8 | 19460097 | IS | CSGALNACT1 | TSS200; Body; 5’UTR | 3.00×10-04 | – 0.116 |
| cg12216772 | 10 | 46164062 | NE | ANUBL1 | 5’UTR | 3.33×10-08 | –0.115 |
| cg06579481 | 7 | 104621597 | NE | – | – | 8.57×10-06 | –0.112 |
| cg19977004 | 11 | 1482563 | IS | BRSK2 | 3’UTR | 4.45×10-04 | – 0.111 |
| cg05116443 | 20 | 62562680 | IS | DNAJC5 | Body | 1.25×10-04 | – 0.110 |
| cg08938155 | 5 | 77043612 | OS | TBCA | Body | 3.68×10-03 | – 0.110 |
| cg15822108 | 4 | 140306311 | OS | NAA15 | Body | 4.28×10-07 | –0.109 |
| cg19841649 | 5 | 4866322 | IS | – | – | 7.58×10-03 | – 0.108 |
| cg26900509 | 11 | 127514 | IS | LOC100133161 | Body | 3.13×10-04 | – 0.108 |
| cg13165070 | 11 | 2154113 | IS | INS-IGF2; IGF2 | Body; 3’UTR | 1.87×10-03 | – 0.107 |
| cg02077481 | 16 | 33939020 | IS | 9.62×10-03 | – 0.106 | ||
| cg02737727 | 14 | 105561470 | SS | LOC102723354 | Body | 1.84×10-09 | –0.105 |
| cg14819618 | 8 | 8180214 | SE | PRAGMIN | Body | 2.26×10-06 | –0.104 |
| cg23621438 | 22 | 25850271 | OS | MIR6817; CRYBB2P1 | TSS1500; Body | 1.84×10-09 | –0.102 |
| cg05992347 | 16 | 33964783 | IS | MIR1826 | TSS1500 | 4.54×10-04 | – 0.101 |
| cg16003687 | 6 | 168613889 | SS | – | – | 3.28×10-05 | – 0.101 |
| cg04479860 | 4 | 190767364 | IS | – | – | 7.15×10-03 | – 0.101 |
| cg06583549 | 19 | 46387962 | IS | IRF2BP1 | 1st Exon | 4.31×10-04 | – 0.101 |
| cg27552418 | 4 | 97598786 | OS | – | – | 1.08×10-03 | 0.104 |
| cg25338438 | 5 | 161276341 | OS | GABRA1 | 5’UTR; TSS1500 | 1.04×10-03 | 0.107 |
| cg09728337 | 10 | 32668256 | OS | EPC1 | TSS1500 | 5.80×10-03 | 0.110 |
| cg20967739 | 1 | 50895827 | SE | – | – | 9.25×10-04 | 0.114 |
| cg06259441 | 3 | 23957589 | NS | RPL15; NKIRAS1 | TSS1500; 5’UTR | 1.48×10-03 | 0.115 |
The positions are ordered according to their Delta β-value. The first 23 CpGs exhibit a lower methylation level in CR-RSV than in sequelae cases, while the following 5 DMPs have an opposite pattern. In bold, positions with the lowest P-value, represented in Figures 5 , 6 . Chr, chromosome; SE, S Shelf; NE, N Shelf; NS, N Shore; SS, S Shore; IS, island; OS, OpenSea; GN, Gene name; GN; GG, Gene group; P-value, FDR P-value.