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. 2022 Aug 27;106(6):1170-1179. doi: 10.1097/TP.0000000000003940

FIGURE 1.

FIGURE 1.

Energy-demanding processes measured during NMP. Porcine kidneys were perfused for 4 h with blood (control) with Aqix supplemented with a colloid (2.2% BSA or 3.5% Dex) or Aqix with a colloid (BSA or Dex) and RBC. A, Oxygen consumption rates during 4 h normothermic perfusion, *P < 0.05 AUCs of all RBC-containing groups compared with acellular groups. B, Fractional sodium excretion levels during 4 h perfusion, *P < 0.02 Aqix-BSA, Aqix-Dex vs controls (Dunnett test). C, TNa during 4 h perfusion, *P < 0.001 control vs Aqix-BSA/Dex and control vs Aqix-Dex-RBC group. D, ATP content in kidney cortex tissue after 30 min warm ischemia and before preservation (HMP0), 3 h preservation (HMP180), 30 min of NMP (NMP30), and at the end of 240 min of NMP (NMP240), #P < 0.03 vs controls. Every group contains 6 kidneys. Data are presented as mean ± SEM. Except for ATP, areas under the curves were compared to assess differences between experimental groups. ATP, adenosine triphosphate; BSA, bovine serum albumin; Dex, dextran 40; HMP, hypothermic machine perfusion; NMP, normothermic machine perfusion; RBC, red blood cell; TNa, total sodium reabsorption.