FIGURE 2.

Renal function and the effects of colloids on the kidney. Porcine kidneys were perfused for 4 h with blood (control) with Aqix supplemented with a colloid (2.2% BSA or 3.5% Dex) or Aqix with a colloid (BSA or Dex) and RBC. A, Renal flow rates during 3 h of HMP and (B) during 4 h NMP; (C) creatinine clearance during 4 h NMP, *P = 0.02 control vs Aqix-Dex-RBC group; (D) total urine production and weight gain, respectively, during 4 h NMP, *P ≤ 0.05. Every group contains 6 kidneys. Data are presented as mean ± SEM. Except for urine production and weight gain, areas under the curves were compared to assess differences between experimental groups. BSA, bovine serum albumin; Dex, dextran 40; HMP, hypothermic machine perfusion; NMP, normothermic machine perfusion; RBC, red blood cell.