Fig. 2.
The effect of nicotine administration on the total distance moved (TDM) by adolescent rats. Animals (n=52) received injections (s.c.) of either saline (n=10) or a low (0.14 or 0.21 mg free base/kg; n=21), moderate (0.42 mg free base/kg; n=11) or high (0.56 mg free base/kg; n=10) dose of nicotine once a day for eight days from PND 35–42. Immediately following injection on PND 35 [One], 38 [Four] and 42 [Eight], TDM was assessed for a total of 5 min. Bars represent mean + sem. * Means differ significantly, p<0.05.