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. Author manuscript; available in PMC: 2022 May 24.
Published in final edited form as: Behav Brain Res. 2012 Jan 24;230(1):62–68. doi: 10.1016/j.bbr.2012.01.036

Fig. 5.

Fig. 5

The effect of nicotine administration on CREB and pCREB in the ventral striatum (vStr) of low locomotor activity (LLA) and high locomotor activity (HLA) adolescent rats. Animals (n=36) were classified as LLA (n=18) or HLA (n=18) as in Fig. 1 and received injections of either saline (n=12), low (n=12) or high (n=12) dose nicotine as in Fig. 2. On PND 43, 18 hours following the final nicotine injection, animals were sacrificed and the vStr dissected for western blot analysis. Bars represent optical density (mean + sem) for CREB and pCREB; data are normalized to the optical density for β-tubulin of each sample. *Means differ significantly, p<0.05.