Typical lesions of palmoplantar pustular psoriasis in 3 different patients free of any mutation in IL36RN, CARD14 and AP1S3 genes. (A) Pustular lesions involving palmar areas of hands, with some degree of acropustular damage, reflecting the possible association between palmoplantar pustular psoriasis and acrodermatitis continua of Hallopeau (ACH). (B) Disseminated pustules of the soles leave dark-brown macular lesions, coexisting with fresh evolutive pustules and erythemato-squamous lesions. (C) Typical lesions of ACH involving the toes, leading to destruction of the nail apparatus.