Table I.
Characteristics of patients with atopic dermatitis (AD)
| Group | Samples n | Age, years Median (range) | Sex% female (n) | SCORAD Median (range) | Total IgE (IU/ml) Median (range) | Asthma % (n) | Rhinitis % (n) | Asthma and rhinitis % (n) |
|---|---|---|---|---|---|---|---|---|
| ELISAa | ||||||||
| Children with AD | 60 | 8 (3–14) | 55.0 (33) | 37.0 (19.9–47.4) | 154.0 (36.50–839.0) | 28.3 (17) | 35.0 (21) | 20.0 (12) |
| Adults with AD | 67 | 30(24–42) | 52.2(35) | 32.0 (16.2–44.5) | 198.0 (61.7–802.0) | 35.8 (24) | 64.2 (43) | 35.0 (21) |
| Healthy controls | 31 | 39 (28 – 51) | 61.3 (19) | - | 40.0 (8.0–59.0) | - | - | - |
| Flow cytometryb | ||||||||
| Adults with AD | 11 | 29 (21.0–43.0) | 27.3 (3) | 54.6 (43.6–64.3) | 1,458 (357–4352) | 18.1 (2) | 27.3 (3) | 9.1 (1) |
| Healthy controls | 10 | 27 (24.0–32.5) | 40.0 (4) | - | - | - | - | - |
a
Serum samples of patients with AD analysed for levels of sOX40 and sOX40L by enzyme-linked immunoassay (ELISA).
b
Peripheral blood mononuclear cells from patients with AD analysed for membrane expression of OX40 and OX40L by flow cytometry.
Healthy controls were matched for age and sex to the patients with AD (for the adult group only).
SCORAD: Subjective SCORing Atopic Dermatitis.