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Collagen XVII (COL17) processing in physiological settings. (A) Schematics of COL17 and sequences of the NC16A domain. (Copyright 2010: The American Association of Immunologists, Inc.). (B) The shed COL17 ectodomain (green: antibody HK139) and laminin 332 (red: antibody 6F12) co-localize in the extracellular matrix of normal human skin. TM: transmembrane. Blue: DAPI. Scale bar: 40 μm. The figures have been partially modified from previous studies (13, 14). Permission given by publisher.
