Fig. 2.

Neoepitope development in the cleaved collagen XVII (COL17) ectodomains. (A) Schematics of linear IgA dermatosis type 1 (LAD-1) and linear IgA bullous disorder (LABD)-97 polypeptides. (B) LAD IgA-class autoantibodies show more intense reactivity to the cleaved COL17 ectodomains LAD-1 and LABD-97 than to full-length COL17. Note that LAD sera numbers 2, 5 and 10 react more strongly to LABD-97. N: normal control. The immunoblotting data have been partially modified from a previous study (23). BP: bullous pemphigoid. Permission given by publisher.