. 2022 May 24;17(5):e0266964. doi: 10.1371/journal.pone.0266964

Table 4. Summary of outcomes by bicluster.

Bicluster #	Radiographic OA	Arthroplasty	Medial narrowing^*	Lateral narrowing^*	Symptoms
Bicluster #	KLG	TKR	medial qJSW	lateral qJSW	WOMAC
1	Less rOA at baseline and less progression	3% TKR	2–18% loss	1–15% loss	95% "stable"
1	Less rOA at baseline and less progression	3% TKR	2–18% loss	1–15% loss	0.1% "improver"
2	Like population	8% TKR	2–28% loss	1–17% loss	83% "stable"
3	Like population	10% TKR	2–32% loss	2–21% loss	80% "stable"
4	Most rOA at baseline, more progression	17% TKR	4–45% loss	0–23% loss	52% "improvers"
4	Most rOA at baseline, more progression	17% TKR	4–45% loss	0–23% loss	4% "worsening"
5	More rOA at baseline, most progression	17% TKR	3–44% loss	3–36% loss	32% "improvers"
5	More rOA at baseline, most progression	17% TKR	3–44% loss	3–36% loss	7% "worsening"
6	Like population	11% TKR	2–31% loss	1–17% loss	88% "stable"

*25^th-75^th percentile (IQR); KLG = Kellgren Lawrence Grade; TKR = total knee replacement; qJSW = quantitative joint space width; WOMAC = Western Ontario and McMaster University Osteoarthritis Index.