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. Author manuscript; available in PMC: 2022 May 24.
Published in final edited form as: Mol Psychiatry. 2021 Jan 4;26(6):2440–2456. doi: 10.1038/s41380-020-00981-3

Fig. 3.

Fig. 3

Downregulation of LEF1 gene and Wnt/β-catenin signaling impairment in NR neurons. a Expression of key Wnt-signaling related genes throughout differentiation starting from NPC (day 0) until day 42. b Vector carrying 7xTcf-eGFP in which eGFP fluorescence is a measure of β-catenin/TCF/LEF1-dependent transcription activity and mCherry fluorescence is a control for the transduced cells. c Barplots show percentage of mCherry-positive cells or percentage of mCherry-positive eGFP-positive cells. Data represent mean ± SEM for n=3 cell lines. Statistical analysis: Mixed linear model. Data distribution for 2 experiments for each cell line is shown in Fig. S7.