Skip to main content
. Author manuscript; available in PMC: 2022 May 24.
Published in final edited form as: Mol Psychiatry. 2021 Jan 4;26(6):2440–2456. doi: 10.1038/s41380-020-00981-3

Fig. 5.

Fig. 5

Hyperexcitability is modulated by VPA and LEF1 expression. a, b, d Extracellular spontaneous firing detected in MEA platform. a Data represent mean ± SEM for n=4 CTL, n=3 LR or n=3 NR cell lines. Statistical analysis: Dunett’s multiple comparisons test LR and NR compared to CTL. Data distribution for 8 wells for each cell line from a representative experiment is shown in Fig. S9. b Data represent mean ± SEM for n=3 NR cell lines. Statistical analysis: Dunett’s multiple comparisons test Li and VPA compared to vehicle. Cell line distribution shown in Fig. S9. c Quantitative PCR showing the mRNA levels of LEF1 gene normalized to ACTB. Data represent mean ± SEM for 3 independent experiments. d Data represent mean ± SEM for n=12 wells for 1 control cell line expressing shLEF1 or shSCR (scrambled control). Statistical analysis: unpaired t-test. e Model of action of VPA and LEF1 on excitability.