Figure 4.

Decision curve analysis for each model in the validation cohort. The net benefit for each model is compared to an “admit-all” (red line) and “admit-none” (green line) approach, and each model containing a biochemical biomarker (purple line) is also compared to the model containing only clinical variables (blue line). A threshold probability of 5% indicates a scenario where the value of 1 TP (patient admitted who will subsequently require oxygen) is equivalent to 19 FPs (patients admitted who will not subsequently require oxygen). Abbreviations: CRP, C-reactive protein; FP, false positive; IL-6, interleukin 6; NLR, neutrophil-to-lymphocyte ratio; PCT, procalcitonin; sTREM-1, soluble triggering receptor expressed on myeloid cell-1; suPAR, soluble urokinase plasminogen activator receptor; TP, true positive.