Table 1.
Clinical characteristics and lab tests at the time of COVID-19 diagnosis according to the induction treatment
| Variables | Basiliximab (n = 73) | Thymoglobulin (n = 54) | P-value |
|---|---|---|---|
| Donor type (DBD/cDCD/LD), n/n/n | 44/22/7 | 29/21/4 | .575 |
| Donor age (years), mean (SD) | 60.7 (14.9) | 59.7 (12.9) | .339 |
| Donor sex (male/female), n/n | 37/35 | 34/18 | .120 |
| Patient age (years), mean (SD) | 59.4 (18.0) | 58.2 (12.7) | .337 |
| Patient age >65 years (yes/no), n/n | 34/39 | 17/37 | .086 |
| Patient sex (male/female), n/n | 46/27 | 31/23 | .523 |
| Arterial hypertension (yes/no), n/n | 64/9 | 46/8 | .684 |
| Diabetes (yes/no), n/n | 33/40 | 15/39 | .045 |
| BMI >30 kg/m2 (yes/no), n/n | 17/56 | 12/41 | .932 |
| Previous cancer (yes/no), n/n | 12/61 | 10/44 | .759 |
| Pneumopathy (yes/no), n/n | 11/62 | 9/45 | .807 |
| Retransplant (yes/no), n/n | 3/70 | 16/38 | .000 |
| cPRA (%), mean (SD) | 5.6 (18.5) | 32.7 (40.8) | .000 |
| HLA mismatch, n (%) | 3.7 (2.2) | 4.2 (2.4) | .198 |
| Maintenance immunosuppression (TAC + MMF + P/TAC + mTORi + P), n/n | 62/11 | 50/4 | .186 |
| DGF (yes/no), n/n | 28/45 | 17/37 | .423 |
| Acute rejection (yes/no), n/n | 3/68 | 4/49 | .428 |
| Transplant to COVID-19 time (months), mean (SD) | 2.5 (2.7) | 3.2 (3.4) | .888 |
| Hospitalization (yes/no), n/n | 63/10 | 44/10 | .461 |
| Nosocomial infection (yes/no), n/n | 33/40 | 23/30 | .840 |
| ARDS (yes/no), n/n | 22/51 | 18/36 | .701 |
| ICU admission (yes/no), n/n | 18/55 | 11/43 | .569 |
| Invasive mechanical ventilation (yes/no), n/n | 13/60 | 9/45 | .867 |
| AKI (yes/no), n/n | 32/36 | 22/30 | .604 |
| Haemodialysis requirement (yes/no), n/n | 15/56 | 13/41 | .654 |
| Death (yes/no), n/n | 54/19 | 40/14 | .990 |
| Survival time (months), mean (SD) | 7.8 (6.3) | 7.2 (5.8) | .289 |
| Laboratory data at the time of diagnosis, mean (SD) | |||
| Creatinine (mg/dL) | 2.7 (2.1) | 2.4 (1.8) | .465 |
| Total lymphocytes (×109/L) | 556 (389) | 426 (361) | .016 |
| D-dimer (ng/mL) | 2961 (5459) | 1591 (1405) | .327 |
| Interleukin-6 (pg/mL) | 113 (296) | 105 (134) | .385 |
| C-reactive protein (mg/dL) | 26.1 (42.5) | 21.6 (35.4) | .830 |
Comparison between groups was performed using Pearson's chi-squared test for categorical data, t-test was used for continuous normally distributed data and Mann–Whitney U test for non-normally distributed data. Statistically significant values are in bold.
DBD, donation after brain death; cDCD, controlled donation after circulatory death; LD, living donation; TAC, tacrolimus; MMF, mycophenolate; P, prednisone.