Table 1.
Critically ill COVID-19 patients’ characteristics, support interventions, SAPS 3 score and outcome in the first and second waves
| Characteristics | First wave(n=290) | Second wave(n=477) | p-Value |
|---|---|---|---|
| Age (years), mean±SD | 59.8 ± 15.2 | 57.1 ± 14.9 | 0.015 |
| Age groups (years), n (%) | 0.206 | ||
| 18–40 | 35 (12.1) | 74 (15.5) | |
| 41–60 | 112 (38.6) | 196 (41.1) | |
| >60 | 143 (49.3) | 207 (43.4) | |
| Gender, n (%) | 0.309 | ||
| Male | 175 (60.3) | 270 (56.6) | |
| Female | 115 (39.7) | 207 (43.4) | |
| Comorbidities, n (%) | |||
| Non-dialysis CKD | 31 (13.1) | 11 (2.8) | <0.001 |
| CKD on dialysis | 4 (1.7) | 7 (1.8) | 0.873 |
| Severe COPD | 8 (3.4) | 9 (2.3) | 0.472 |
| Arterial hypertension | 153 (64.8) | 232 (59.2) | 0.198 |
| Diabetes | 91 (38.6) | 119 (31.8) | 0.088 |
| Morbid obesity | 56 (23.7) | 132 (33.7) | 0.016 |
| Support interventions in the ICU, n (%) | |||
| Mechanical ventilation | 233 (80.6) | 332 (67.2) | <0.001 |
| Non-invasive ventilation | 2 (0.7) | 126 (25.5) | <0.001 |
| Vasopressors | 197 (68.2) | 197 (39.9) | <0.001 |
| RRT | 102 (35.3) | 83 (16.8) | <0.001 |
| Vital signs and kidney and pulmonary aspects on ICU admission | |||
| Lowest systolic blood pressure (mmHg), mean±SD | 89.2±8.5 | 100.6±23.7 | <0.001 |
| Lowest diastolic blood pressure (mmHg), mean±SD | 52.8±9.4 | 56.7±16.6 | <0.001 |
| Lowest mean arterial pressure (mmHg), mean±SD | 64.8±8.6 | 71.3±18.4 | <0.001 |
| Highest respiratory rate (breaths/min), mean±SD | 33.5±2.7 | 29.1±4.3 | <0.001 |
| Highest creatinine level (mg/dL), median (IQR) | 1.6 (0.9–2.5) | 0.9 (0.7–2.1) | <0.001 |
| Lowest oxygenation index, median (IQR) | 39 (25–73) | 59 (34–93) | <0.001 |
| Urea (mg/dL), median (IQR) | 80 (45–130) | 64 (39–112) | 0.092 |
| SAPS 3 score, median (IQR) | 70 (55–78) | 59 (49–70) | <0.001 |
| Intensive care unit stay (days), median (IQR) | 11 (6–18) | 11 (7–18) | 0.941 |
| Outcome, n (%) | 0.112 | ||
| Survivors | 133 (45.9) | 247 (51.8) | |
| Non-survivors | 157 (54.1) | 230 (48.2) |