Table 1.
CRP values in animal model studies.
| Animal model | T2DM induction | CRP values | Diabetes-associated disorders | Ref. |
|---|---|---|---|---|
| Sprague-Dawley male rats | High-glucose/high-fat diets (15 weeks), and streptozotocin (single dose 30 mg/kg i.p.) | Increased | Irregular cardiac muscle fibers and degenerative necrosis | [148] |
| Sprague-Dawley male rats | High-fat diet (10 weeks), and streptozotocin (single dose 25 mg/kg, i.p.) | Increased | Altered oxidative stress parameters in the pancreas and serum | [196] |
| Sprague-Dawley male rats | High-fat and high-sugar (5 weeks), and streptozotocin (7 days, dose 30 mg/kg, i.p.) | Increased | Injury of the intestinal mucosa reduced antioxidant capacity | [197] |
| Wistar male rats | High-fat diet (10 weeks), and streptozotocin (single dose 40 mg/kg i.p.) | Increased | Elevated systolic blood pressure, congested blood vessels, necrosis, and inflammation of the heart, pancreas, liver, and kidney. | [198] |
| Wistar male rats | High-fat diet (10 weeks) and alloxan (single dose 50 mg/kg, i.p.) | Similar to the control values | Physiological pancreas cytoarchitecture, altered lipid profile | [151] |
| Wistar male rats | Streptozotocin (60 mg/kg i.p.) | Increased | Aorta smooth muscle cell proliferation, altered lipid profile | [21] |
| Wistar male rats | Streptozotocin (single dose 55 mg/kg i.p.) | Increased | Increased cytokine levels | [22] |
| Sprague-Dawley male rats | Streptozotocin (two-dose within two days 40 mg/kg i.p.) | Increased | Endothelial dysfunction, modified protein profile | [149] |
| Wistar male rats | Alloxan monohydrate (single dose 120 mg/kg i.p.) | Increased | Hypercholesterolemia | [150] |
| Wistar male rats | High-fat, high-fructose, high-casein diet (3 months) and streptozotocin (60 mg/kg in 2 equally doses with a 12 h interval i.p. and 20–30 mg/kg after 2 weeks for some animals) | Increased | Systolic blood pressure deviations | [155] |
| Wistar male rats | Streptozotocin (single dose 55 mg/kg i.p.) | Increased | Altered lipid profile increased glycosylated hemoglobin and liver enzymes, decreased levels of antioxidant enzymes | [156] |
| Wistar male rats | Alloxan monohydrate (single dose 120 mg/kg i.p.) | Increased | Altered oxidative stress parameters in serum | [153] |
| Albino rats | Alloxan monohydrate (single dose 120 mg/kg i.p.) | Increased | Altered oxidative stress parameters in serum, pathological pancreas cytoarchitecture | [154] |
| Wistar male rats | Streptozotocin three doses (for 3 continuous days 45 mg/kg i.p.) | Increased | Altered oxidative stress parameters in the kidneys | [199] |
CRP: C-reactive protein; T2DM: type 2 diabetes mellitus.