Table 1.

LIGHT in disease and clinical applications

Disease	LIGHT function and evidence
COVID-19	LIGHT expression as a prognostic biomarker in COVID-19 (Arunachalam et al., 2020; Perlin et al., 2020; Tan et al., 2021)
IBD	Reduced intestinal inflammation by LIGHT neutralization in a colitis model (Jungbeck et al., 2009)
Asthma, IPF, SSc	LIGHT drives fibrosis and tissue remodeling in the lung (Doherty et al., 2011; Herro et al., 2015)
Atopic dermatitis, scleroderma	LIGHT induces changes in keratinocytes and promotes epidermal and dermal thickening (Herro et al., 2015, 2018)
Metabolic diseases	Elevated LIGHT level in patients with type 2 diabetes (Halvorsen et al., 2016) LIGHT-mediated inflammation implicated in nonalcoholic fatty liver disease (Herrero-Cervera et al., 2019)
Postmenopausal osteoporosis	Antagonizing LIGHT could be therapeutically beneficial in patients with postmenopausal osteoporosis (Brunetti et al., 2020)
Cancer	LIGHT was found to play a role in antitumor immunity (Holmes et al., 2014) LTβR signaling implicated in tumor metastasis by inducing anti-tumor effector cells (Lu and Browning, 2014)
RA	Lymphotoxin/LIGHT axis decreases the IFN signature in patients’ blood cells (Bienkowska et al., 2014)