Table 1.
dose statistics of VMAT, IMPT and TB-plans for 3-, 5- and 10-beams (3b, 5b, 10b). Maximum and mean doses are given in Gy, volume receiving x Gy (VxGy) in cm3. Column ‘RTOG 0915’ lists the requirements given by the RTOG 0915 trial. Columns ‘1-6’ give the averages for patients 1-6 (small lung lesions), columns ‘7’ the dose statistics of patient 7 (larger tumor). Empty cells denote zeros.
| Structure | Metric | RTOG 0915 |
VMAT |
IMPT |
TB 3b |
TB 5b |
TB 10b |
TB 5b-VMAT | TB 5b-IMPT | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1-6 | 7 | 1-6 | 7 | 1-6 | 7 | 1-6 | 7 | 1-6 | 7 | 1-6 | 1-6 | |||
| Spinal cord | max | 14Gy | 4.1 | 7.5 | 0.3 | 6.3 | 3.4 | 10.7 | 2.0 | 8.3 | 2.2 | 7.6 | -2.1* | 1.7 |
| V10Gy | <0.35cm3 | |||||||||||||
| V7Gy | <1.2cm3 | 1.0 | 0.1 | |||||||||||
| Esophagus | mean | 1.6 | 6.0 | 0.1 | 1.6 | 1.7 | 2.9 | 3.3 | -1.6⁎⁎ | -0.1 | ||||
| max | 15.4Gy | 4.0 | 12.0 | 1.0 | 9.7 | 8.8 | 0.4 | 6.8 | 0.9 | 6.0 | -3.6⁎⁎ | -0.6 | ||
| V11.9Gy | <5cm3 | |||||||||||||
| V8Gy | 2.9 | 0.1 | 0.1 | |||||||||||
| Heart | mean | 0.9 | 0.2 | 0.5 | 0.5 | 0.5 | 0.5 | -0.4* | -0.1 | |||||
| max | 22Gy | 7.0 | 0.4 | 4.9 | 6.9 | 6.5 | 6.6 | -0.4 | 1.6 | |||||
| V16Gy | <15cm3 | |||||||||||||
| Trachea | mean | 0.6 | 6.4 | 0.1 | 2.2 | 4.1 | 4.3 | 3.4 | -0.6 | -0.1 | ||||
| max | 20.2Gy | 4.6 | 16.3 | 2.2 | 9.8 | 1.2 | 14.1 | 0.4 | 9.5 | 0.5 | 9.5 | -4.2* | -1.8 | |
| V10.5Gy | <4cm3 | 3.3 | 1.8 | |||||||||||
| V8Gy | 6.5 | 0.1 | 4.7 | 1.5 | 0.8 | |||||||||
| Ribs | mean | 2.2 | 5.8 | 0.8 | 2.9 | 1.6 | 5.0 | 1.5 | 5.1 | 1.5 | 4.9 | -0.6⁎⁎ | 0.8⁎⁎ | |
| max | 30Gy | 21.0 | 38.1 | 22.2 | 36.5 | 25.1 | 37.3 | 23.1 | 36.4 | 22.6 | 36.7 | 2.1 | 0.9 | |
| V22Gy | <1cm3 | 1.4 | 58.7 | 1.0 | 42.9 | 1.8 | 57.0 | 1.2 | 51.5 | 1.1 | 54.7 | -0.1 | 0.2 | |
| V16Gy | 6.3 | 127.1 | 3.0 | 71.8 | 12.6 | 83.4 | 5.4 | 87.4 | 4.4 | 83.8 | -0.9 | 2.4 | ||
| V12Gy | 22.3 | 176.8 | 9.1 | 97.0 | 50.9 | 207.7 | 18.5 | 120.2 | 13.8 | 116.0 | -3.8 | 9.4 | ||
| Skin | mean | 1.2 | 4.0 | 0.4 | 1.1 | 1.0 | 4.1 | 0.9 | 3.8 | 0.9 | 3.9 | -0.3⁎⁎ | 0.5⁎⁎ | |
| max | 26Gy | 9.4 | 16.4 | 10.9 | 12.9 | 18.0 | 18.7 | 14.1 | 15.1 | 12.7 | 13.8 | 4.7⁎⁎ | 3.2 | |
| V23Gy | <10cm3 | 0.1 | -0.1 | |||||||||||
| V16Gy | 1.3 | 0.4 | ||||||||||||
| V10Gy | 27.3 | 0.6 | 6.3 | 12.4 | 74.2 | 3.9 | 26.3 | 1.1 | 31.8 | 3.9⁎⁎ | 3.4⁎⁎ | |||
| Lung (c) | mean | 0.4 | 1.1 | 0.1 | 0.1 | 0.4 | 0.1 | 1.0 | -0.3⁎⁎ | 0.1 | ||||
| V20Gy | ||||||||||||||
| V10Gy | 0.2 | 2.4 | 5.8 | 3.3 | 1.2 | 0.1 | 3.3 | 3.3 | ||||||
| V5Gy | 0.5 | 23.8 | 5.1 | 9.7 | 16.9 | 67.0 | 22.1 | 112.0 | 16.4 | 16.9 | ||||
| Lung (i) | mean | 2.6 | 5.1 | 1.7 | 3.8 | 2.0 | 4.3 | 1.4 | 4.3 | 1.9 | 4.3 | -1.1 | -0.2 | |
| V20Gy | 40.5 | 197.9 | 43.5 | 150.6 | 42.7 | 183.7 | 38.8 | 184.2 | 37.0 | 173.5 | -1.7 | -4.6 | ||
| V10Gy | 147.4 | 347.4 | 112.9 | 255.7 | 179.4 | 329.7 | 142.1 | 314.6 | 135.0 | 312.5 | -5.3 | 29.3 | ||
| V5Gy | 323.1 | 439.2 | 197.6 | 331.4 | 253.8 | 373.2 | 270.5 | 389.8 | 258.1 | 377.7 | -52.6 | 72.9⁎⁎ | ||
| Lungs-ITV† | mean | 1.4 | 3.0 | 0.8 | 1.8 | 1.0 | 2.2 | 1.0 | 2.3 | 1.0 | 2.5 | -0.5⁎⁎ | 0.2 | |
| V20Gy | 37.2 | 178.3 | 40.2 | 131.0 | 39.5 | 164.1 | 35.7 | 164.5 | 33.9 | 153.9 | -1.5 | -4.5 | ||
| V10Gy | 144.0 | 328.0 | 109.7 | 236.0 | 178.8 | 315.8 | 142.3 | 294.9 | 132.9 | 293.0 | -1.8 | 32.6⁎⁎ | ||
| V7.4Gy | <1000cm3 | 210.1 | 373.0 | 147.1 | 275.4 | 220.4 | 340.4 | 213.8 | 354.8 | 202.1 | 354.8 | 3.7 | 66.7⁎⁎ | |
| V7Gy | <1500cm3 | 223.7 | 381.0 | 153.9 | 281.7 | 226.1 | 344.4 | 224.9 | 371.6 | 214.8 | 370.8 | 1.2 | 71.0⁎⁎ | |
| V5Gy | 320.3 | 443.5 | 194.2 | 311.7 | 255.5 | 363.2 | 283.9 | 437.1 | 276.9 | 470.0 | -36.5 | 89.6⁎⁎ | ||
| body | mean | 0.6 | 1.7 | 0.2 | 0.8 | 0.4 | 1.3 | 0.4 | 1.4 | 0.4 | 1.4 | -0.2⁎⁎ | 0.1⁎⁎ | |
⁎
0.01 < p-value < 0.05;
⁎⁎
p-value < 0.01; paired t-test with alpha = 0.05
†
Note: RTOG0915 requirements are for Lungs-GTV