Fig. 5.

In vivo antitumor efficacy on a 4T1 breast cancer mice model. Once the tumor volumes reached ∼50 ​mm³, mice were intravenously injected with PBS, Taxol, pep, pep-PAPM, or pep-PAPM@PTX every other day for a total of 5 treatments (pep eq. dose of 6 ​mg/kg, PTX eq. dose of 10 ​mg/kg). (a) Tumor volume change of the mice after intravenous injection over time. (b) Image of resected tumors. (c) Weights of extracted tumors at the end of the treatment procedure. (d) Changes in body weight during the treatment. (e) H&E staining of tumors in different groups. Scale bar: 150 ​μm.