Fig. 6.
The anti-breast cancer effect of IC/IR820 NPs in vivo. (A) In vivo distribution of IR820 and IC/IR820 NPs at different times. (B) Schematic illustration of the procedure of tumor treatment in vivo. Created with BioRender.com. (C) In vivo thermal imaging of different groups of treated mice. (λ = 808 nm, P = 1.0 W/cm2; irradiation time = 5 min). (D) Representative images of isolated tumors. Scale bar: 1 cm. (E) The volume of tumors from each group (5 mice per group) was measured at the indicated time points. (F) The body weight of mice in each group was measured at the indicated time points. (G) The weight of individual tumors and the inhibition rate. (H–L) Representative immunohistochemistry images of mice treated with vehicle, IR820, or IC/IR820 NPs intravenously through tail vein at the indicated time points, quantification of Ki67, 8-OHDG, cleaved-caspase 3, and LC3B expression score. Scale bar: 50 μm. (λ = 808 nm, P = 1.0 W/cm2; irradiation time = 5 min).