Table 1.

The effect of an injection of EEDQ on the potency of eticlopride and SCH23390 to elevate the rate of cocaine self-administration and the satiety threshold (Dst).

Competitive antagonists	Ratio before EEDQ		Ratio after EEDQ		n
	Rate	DST	Rate	DST
Eticlopride (20 nmol/kg)	1.80 ± 0.07	2.08 ± 0.07	1.93 ± 0.11	2.12 ± 0.13	5
SCH23390 (20 nmol/kg)	2.20 ± 0.11	2.84 ± 0.13	2.31 ± 0.20	3.12 ± 0.22	4

The ratio of the rate of cocaine maintained self-administration and the peak satiety threshold after injection of competitive antagonist compared to values prior to injection. Ratios were not significantly different before or after EEDQ treatment for either eticlopride or SCH23390.