Fig. 5. Characterisation of CD8⁺ T and CD103⁺CD8⁺ T_RM cells infiltration across molecular features and prognostic value under prime mutations.

a The landscape of molecular subtype, AJCC stage, grade, tumour mutation burden (TMB) and various genomic alterations sorted by basket across CD8⁺ T cells (left panel) and T_RM (right panel) subgroups in TCGA-BLCA cohort. b Hazard ratio of mortality for patients with (right panel) or without (left panel) specific gene mutations according to CD8⁺ T cells (blue) and T_RM (red) subgroups in ACT-applied patients from TCGA-BLCA cohort. WT wild type, MUT mutation. TMB ≥ 10 mut/Mb was defined as TMB^high group, while TMB < 10 mut/Mb was defined as TMB^low group. Pearson’s chi-square test was applied for studying the relationship between different cell infiltration subgroups and molecular subtype, AJCC stage, grade, tumour mutation burden (TMB), various genomic alterations. Cox regression analyses were applied for survival analysis. P ≤ 0.05 was considered statistical significance. AJCC American Joint Committee on Cancer.