Table 2.
Characteristics of the included studies
| References | Article type | OCEBM rating | NHI-SQAT rating | Patients with CIMDL/overall number of study patients | Sex distribution (F:M) | Age (years) | Specific subgroup of CIMDL patients studied |
|---|---|---|---|---|---|---|---|
| Alexandrakis et al. [17] | CS | 4 | Good | 7/7 | 2:5 | 39 ± 4.25 (36–58) | Patients with NLDO and SP |
| Armengot et al. [18] | CS | 4 | Fair | 2/10 | 0:2 | 44; 44 | Patients with vasculitis-like presentation |
| Businco et al. [1] | CS | 4 | Fair | 11/104 | n/a for the CIMDL subsample | None | |
| Colletti et al. [19] | CS | 4 | Good | 4/4 | 3:1 | 35; 37; 39; 41 | Patients with PP |
| Colletti et al. [4] | CS | 4 | Good | 4/4 | 3:1 | 36; 39; 43; 46 | Patients requiring surgical management |
| Green et al. [20] | CS | 4 | Good | 8/9 | 1:7 | 41.5 ± 11.25 (25–49) | None |
| Lanzillotta et al. [21] | CS | 4 | Good | 3/11 | 2:1 | 31; 41; 60 | IgG4 positive patients |
| Kuriloff and Kimmelman [3] | CS | 4 | Fair | 5/5 | 4:1 | 37 ± 9 (28–38) | Patients with osteocartilaginous necrosis |
| Marí et al. [2] | CS | 4 | Fair | 3/3 | 2:1 | 30; 35; 37 | None |
| Medina et al. [22] | CS | 4 | Poor | 11/11 | n.a | < 50 | Patients with SP |
| Plaza et al. [23] | CS | 4 | Fair | 3/10 | 1:2 | 30; 31; 31 | Patients with vasculitis-like presentation |
| Sercarz et al. [24] | CS | 4 | Good | 5/5 | 2:3 | 25; 35; 25; 59; 25 | None |
| Subesinghe et al. [25] | CS | 4 | Poor | 6/14 | 2:4 | 39.5 ± 3.25 (25–45) | ANCA or IgG4 positive patients |
| Trimarchi et al. [10] | CS | 4 | Good | 18/39 | 8:10 | Mean 35, SD 10, median 37, range 22–66 | Patients with vasculitis-like presentation |
| Trimarchi et al. [26] | CS | 4 | Good | 25/25 | 10:15 | 38 ± 10 (22–66) | None |
| Trimarchi et al. [12] | CS | 4 | Good | 10/10 | 2:8 | Range 28–60 | Patients with vasculitis-like presentation |
| Walton et al. [27] | CS | 4 | Fair | 2/11 | 2:0 | 37.8; 42.8 | Patients with nasal deformity |
Age is reported as median ± interquartile range (minimum–maximum) unless otherwise stated; for studies with 4 or fewer subjects individual ages are reported
OCEBM Oxford Centre for Evidence-Based Medicine, NHI-SQAT National Heart, Lung, and Blood Institute Study Quality Assessment Tools, CIMDL cocaine-induced midline destructive lesion, F female, M male, CS case series, N/A not available, SD standard deviation, IQR interquartile range, NLDO nasolacrimal duct obstruction, SP septal perforation, PP palatal perforation