Table 2.

Number and proportion of patients diagnosed with cancer within a year after presenting to primary care with fatigue compared to general population estimates, by gender and age band.

	Patients with fatigue			England population
	Cancera		Total	Cancerb		Total
	n	% [lci,uci]	N	n	% [lci,uci]	N	Absolute difference (%)	Risk ratio [lci,uci]	P-value
Men
30–34	<5c	–	4,741	1,074	0.06 [0.06,0.06]	1,765,282	–	–	–
35–39	12	0.19 [0.1,0.34]	6,206	1,299	0.07 [0.07,0.08]	1,755,657	0.12	2.61 [1.35,4.58]	0.001
40–44	19	0.25 [0.15,0.39]	7,619	2,183	0.11 [0.11,0.12]	1,921,918	0.14	2.2 [1.32,3.44]	0.001
45–49	30	0.37 [0.25,0.52]	8,177	3,804	0.2 [0.19,0.2]	1,926,100	0.17	1.86 [1.25,2.66]	0.001
50–54	80	1 [0.79,1.24]	8,040	6,166	0.36 [0.35,0.37]	1,698,988	0.63	2.74 [2.17,3.42]	<0.001
55–59	117	1.47 [1.21,1.76]	7,981	10,086	0.68 [0.67,0.69]	1,484,784	0.79	2.16 [1.78,2.59]	<0.001
60–64	208	2.37 [2.06,2.72]	8,761	17,610	1.13 [1.12,1.15]	1,551,998	1.24	2.09 [1.82,2.4]	<0.001
65–69	254	3.63 [3.2,4.11]	6,996	21,197	1.71 [1.68,1.73]	1,242,613	1.92	2.13 [1.87,2.41]	<0.001
70–74	298	4.54 [4.04,5.08]	6,568	22,369	2.32 [2.29,2.35]	963,578	2.22	1.95 [1.74,2.19]	<0.001
75–79	362	5.65 [5.09,6.27]	6,402	21,219	2.79 [2.75,2.83]	761,127	2.87	2.03 [1.82,2.25]	<0.001
80–84	328	6.47 [5.79,7.21]	5,072	16,448	3.14 [3.09,3.19]	524,192	3.33	2.06 [1.84,2.3]	<0.001
85+	275	6 [5.32,6.76]	4,580	13,253	3.4 [3.34,3.46]	389,909	2.61	1.77 [1.56,1.99]	<0.001
Women
30–34	22	0.14 [0.08,0.21]	16,237	1,668	0.09 [0.09,0.1]	1,763,868	0.04	1.43 [0.9,2.18]	0.092
35–39	32	0.17 [0.12,0.24]	18,738	2,693	0.15 [0.15,0.16]	1,766,715	0.02	1.12 [0.76,1.59]	0.522
40–44	59	0.29 [0.22,0.38]	20,201	4,823	0.25 [0.24,0.25]	1,959,565	0.05	1.19 [0.9,1.53]	0.190
45–49	99	0.5 [0.4,0.6]	19,965	7,705	0.39 [0.38,0.4]	1,965,976	0.10	1.27 [1.03,1.54]	0.020
50–54	119	0.71 [0.59,0.85]	16,747	9,689	0.56 [0.55,0.57]	1,723,591	0.15	1.26 [1.05,1.51]	0.011
55–59	137	0.98 [0.82,1.16]	13,988	10,687	0.7 [0.69,0.72]	1,518,717	0.28	1.39 [1.17,1.65]	<0.001
60–64	219	1.71 [1.49,1.95]	12,810	15,768	0.98 [0.96,0.99]	1,610,293	0.73	1.75 [1.52,2]	<0.001
65–69	231	2.15 [1.88,2.44]	10,754	16,415	1.25 [1.23,1.27]	1,315,007	0.90	1.72 [1.5,1.96]	<0.001
70–74	238	2.29 [2.01,2.6]	10,384	15,681	1.46 [1.44,1.49]	1,070,973	0.83	1.57 [1.37,1.78]	<0.001
75–79	316	2.94 [2.62,3.28]	10,748	15,805	1.72 [1.7,1.75]	917,204	1.22	1.71 [1.52,1.91]	<0.001
80–84	307	3.43 [3.05,3.83]	8,961	14,821	2 [1.97,2.03]	741,655	1.43	1.71 [1.53,1.92]	<0.001
85+	321	3.23 [2.89,3.61]	9,930	16,778	2.09 [2.06,2.12]	803,409	1.14	1.55 [1.38,1.73]	<0.001

^aCancer diagnoses between 2007 and 2014, 12 months after first presentation with fatigue to primary care in 2007–2013, while aged 30–99 years.

^bEstimated 12-month population incidence, based on annual number of cancer diagnoses and mid-year population estimates for England, 2011. Available population estimates include patients aged >99 years. This was estimated to account for <0.9% of people aged 85+ in this analysis, thus would have a negligible impact on cancer incidence estimates for this age group. ^cCell counts under 5 are suppressed to reduce statistical disclosure risk.