Table 2.

Univariate survival analysis of candidate indices and systemic inflammatory markers for OS and PFS in the discovery set.

	Overall survival			Progression-free survival
	HR (95% CI)	P-value	C-index (SE)	HR (95% CI)	P-value	C-index (SE)
Continuous
PINI	0.371 (0.320–0.431)	<0.001	0.677 (0.013)	0.424 (0.369–0.486)	<0.001	0.649 (0.012)
LMR	0.716 (0.670–0.764)	<0.001	0.659 (0.014)	0.764 (0.723–0.808)	<0.001	0.632 (0.013)
MAR	1.004 (1.003–1.005)	<0.001	0.628 (0.014)	1.004 (1.003–1.004)	<0.001	0.611 (0.013)
NLR	1.123 (1.096–1.151)	<0.001	0.648 (0.014)	1.111 (1.084–1.139)	<0.001	0.618 (0.013)
PLR	1.003 (1.002–1.003)	<0.001	0.612 (0.014)	1.565 (1.323–1.851)	<0.001	0.559 (0.011)
PNI	0.922 (0.910–0.934)	<0.001	0.666 (0.014)	0.933 (0.923–0.944)	<0.001	0.635 (0.013)
Dichotomous
PINI
<3.0	1			1
≥3.0	0.346 (0.287–0.418)	<0.001	0.628 (0.012)	0.412 (0.348–0.487)	<0.001	0.603 (0.011)
LMR
<2.4	1			1
≥2.4	0.338 (0.278–0.412)	<0.001	0.601 (0.011)	0.404 (0.336–0.484)	<0.001	0.586 (0.010)
MAR
<192	1			1
≥192	2.874 (2.326–3.550)	<0.001	0.582 (0.011)	2.296 (1.883–2.799)	<0.001	0.562 (0.009)
NLR
<5.0	1			1
≥5.0	2.399 (1.849–3.112)	<0.001	0.545 (0.009)	2.013 (1.577–2.571)	<0.001	0.536 (0.008)
PLR
<150	1			1
≥150	1.831 (1.515–2.215)	<0.001	0.580 (0.012)	1.565 (1.323–1.851)	<0.001	0.559 (0.011)
PNI
<45	1			1
≥45	0.365 (0.302–0.441)	<0.001	0.618 (0.012)	0.430 (0.362–0.510)	<0.001	0.597 (0.011)

CI confidence interval, SE standard error, HR hazard ratio, PINI prognostic immune and nutritional index, LMR lymphocyte-to-monocyte ratio, MAR monocyte-to-albumin ratio, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, PNI prognostic nutritional index.