Fig. 4.

Depletion of Elovl2 led to chronic inflammation, cellular senescence and adult stem cell exhaustion. a Inflammatory factors levels in blood measured by ELISA (n = 6 per group). Error bars, SEM. Levels of significance were calculated with two-tailed Student’s t test. b Western blotting of TNF-α and MCP-1 (n = 3). c Masson’s trichrome staining on liver. Error bars, SEM. Scale bar, 100 µm. For each group 40 slices from five mice were sed for statistical analysis. Levels of significance were calculated with two-tailed Student’s t test. d Hair follicles and intestines stained with the epithelial progenitor cell markers. Scale bar, 100 µm. Error bars, SEM. For each group 40 slices from five mice were sed for statistical analysis. Levels of significance were calculated with two-tailed Student’s t test