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. 2022 Jan 11;126(11):1570–1580. doi: 10.1038/s41416-021-01692-4

Fig. 6. The interplay between immunophenotypes and intrinsic molecular subtypes.

Fig. 6

a UMAP plot visualising spatial distributions of intrinsic molecular subtypes based on the infiltration levels of 28 immune subpopulations. b Boxplot showing the distribution of tumour-infiltrating lymphocytes between the different intrinsic molecular subtypes. Statistical analysis was performed using a one-way ANOVA and a Wilcoxon rank-sum test. c Visualisation of the four novel immunophenotypes based on the crosstalk between CD8+ T and regulatory T cells (Tregs) for HGSOC tumours. d Kaplan–Meier curves of overall survival between the different immunophenotypes. Statistical analysis was performed using a log-rank test. **P < 0.01, ***P < 0.001. n.s. not significant, mUC metastatic urothelial cancer.