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. 2022 May 24;13:2874. doi: 10.1038/s41467-022-30602-2

Fig. 2. Permeation pathway analysis of the pore domains of TRPV14 °C, class I, TRPV14 °C, class II, TRPV125 °C, class A, TRPV14 °C, class III, TRPV125 °C, class B, and TRPV148 °C, class α.

Fig. 2

a–d Only two subunits are shown for clarity, with S6 helix (S6), pore loop (PL) and pore helix (PH) as indicated. Diagonal distances at the two narrowest restriction points are shown. e Pore radii calculated using the HOLE program for representative TRPV1 structures as color-coded. The radius of water is 1.5 Å, while 2.0 Å is considered the minimal radius for a hydrophobic gate to be open. Residues corresponding to the SF (M644 and G643) and the S6 gate (I679) are denoted.