Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 24;13:2874. doi: 10.1038/s41467-022-30602-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a Cylinder representation of TRPV1 in turquoise (one subunit) and gray (the rest of the channel). The approximate distances from the RTx binding site (reference residue Y511) to subdomains are shown. b The cryo-EM densities (surface) and respective models (sticks) depicting close-up views of the vanilloid binding sites in TRPV1^{C, RTx} (skyblue), thresholding 0.19, TRPV1^{IO, RTx} (yellow), thresholding 0.04, and TRPV1^{O, RTx} (pink), thresholding 0.033. c The cryo-EM densities (surface) and respective models (sticks) depicting close-up views of the selectivity filter in TRPV1^C,RTx (skyblue), thresholding 0.19, TRPV1^IC,RTx (green), thresholding 0.04, TRPV1^IO,RTx (yellow), thresholding 0.1, and TRPV1^O,RTx (pink), thresholding 0.033. d–e Close-up view of the overlays of TRPV1^{C, RTx} (skyblue), TRPV1^{IO, RTx} (yellow), and TRPV1^{O, RTx} (pink) regarding the cytoplasmic domain, and S6 gate e, respectively.