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In the unstimulated apo state, the channel is closed both at the selectivity filter and S6 gate. 1 Initially, RTx binds with no significant conformational changes. 2 RTx binding induces S6 gate dilation. 3 The M644 sidechain flips outward, and the CD moves towards the channel core. 4 Finally, rearrangement of the PL, PH, TJ results in further dilation of the S6 gate.
