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. 2022 May 24;12:8759. doi: 10.1038/s41598-022-12762-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Correlation map between the clinical data in patients with liver disease by Spearman’s correlation analysis. The positive correlation between the data is shown in orange, while the negative correlation between the data is shown in blue. (B) Correlation of serum GDF15 levels and clinical data in patients with liver disease by Spearman’s correlation analysis. Serum GDF15 levels had significant positive correlations with TB, AST, PT-INR, M2BPGi, and Fib4 index. However, serum GDF15 levels were negatively correlated with albumin levels. GDF15, growth differentiation factor 15; TB, total bilirubin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; PT-INR, prothrombin time-international normalized ratio; M2BPGi, Mac-2 binding protein glycosylation isomer; Ig, immunoglobulin; AFP, alpha-fetoprotein.