Table 1.
Clinical characteristics of patients with liver diseases.
| Healthy control | HB | HC | PBC | AIH | |
|---|---|---|---|---|---|
| number | 74 | 17 | 15 | 20 | 45 |
| age (years) | 35.0 ± 8.3 | 50.6 ± 11.4 | 56.1 ± 17.4 | 53.7 ± 10.6 | 60.2 ± 12.9 |
| gender(Female:Male) | 44:30 | 6:11 | 8:7 | 18:2 | 39:6 |
| non-LC:LC | 9:8 | 6:9 | 20:0 | 31:14 | |
| TB (mg/dL) | 1.0 ± 0.4 | 1.0 ± 0.4 | 0.8 ± 0.3 | 2.6 ± 3.1 | |
| AST (IU) | 51.6 ± 19.6 | 49.3 ± 27.7 | 42.3 ± 21.8 | 291.8 ± 448.3 | |
| ALT (IU) | 61.4 ± 30.6 | 49.1 ± 35.1 | 59.6 ± 77.9 | 364.5 ± 511.0 | |
| LDH (U/L) | 182.6 ± 32.6 | 206.0 ± 54.1 | 192.9 ± 30.8 | 286.3 ± 155.4 | |
| GGT (U/L) | 79.4 ± 70.3 | 62.3 ± 74.0 | 210.2 ± 172.8 | 213.3 ± 218.4 | |
| Albumin (g/dL) | 4.1 ± 0.4 | 3.9 ± 0.4 | 4.1 ± 0.3 | 3.5 ± 0.5 | |
| Platelet (× 104/μL) | 14.4 ± 6.1 | 12.8 ± 6.9 | 23.4 ± 6.3 | 17.8 ± 6.9 | |
| PT(INR) | 1.09 ± 0.10 | 1.04 ± 0.08 | 0.96 ± 0.06 | 1.13 ± 0.16 | |
| M2BPGi | 2.0 ± 2.3 | 4.9 ± 4.2 | 0.9 ± 0.4 | 5.9 ± 4.1 | |
| Type IV collagen (ng/mL) | 133.0 ± 12.1 | 185.8 ± 67.5 | 128.0 ± 52.9 | 275.9 ± 191.4 | |
| Fib4 index | 3.3 ± 2.6 | 4.3 ± 2.6 | 1.5 ± 0.7 | 5.9 ± 4.5 | |
| IgG (mg/dL) | 1592.9 ± 404.3 | 1917.6 ± 651.9 | 1575.3 ± 428.7 | 2667.2 ± 901.6 | |
| IgM (mg/dL) | 127.4 ± 38.9 | 134.3 ± 65.1 | 272.8 ± 178.1 | 234.2 ± 218.9 | |
| AFP (ng/mL) | 12.7 ± 19.5 | 11.3 ± 12.9 | 3.8 ± 2.8 | 30.9 ± 66.7 | |
| GDF15 (pg/dL) | 475.3 ± 145.3 | 953.2 ± 871.4 | 1568.0 ± 822.3 | 643.9 ± 247.0 | 1994.3 ± 1258.0 |
HB, hepatitis B; HC, hepatitis C; PBC, primary biliary chorangitis; AIH, autoimmune hepatitis; LC, liver cirrhosis; TB, total bilirubin; AST, asparatate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; GGT, γ-glutamyl transpeptidase; PT, prothrombin time; INR, international normalized ratio; M2BPGi, Mac-2 binding protein glycosylation isomer; Ig, immunoglobulin; AFP, arfa-fetoprotein; GDF15, growth differentiated factor 15.